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26 września, 2025

Transcriptomic profiling of skeletal muscle in the DMDmdx rat model of Duchenne muscular dystrophy

Scientific Reports (2025). DMD, caused by Dmd mutation, was studied in Sprague–Dawley DMDmdx rats using histopathology, biochemistry, and RNA-seq of dystrophic skeletal muscle. DMDmdx rats showed multifocal necrosis, fibrosis, inflammation, elevated muscle-damage enzymes, reduced antioxidant defenses, and increased lipid peroxidation versus WT. RNA-seq identified 3,615 DEGs impacting contraction/ECM/cytoskeleton, with MAPK and immune pathways upregulated and ECM downregulated, underscoring intracellular-signaling targets and the DMDmdx rat’s translational value. https://doi.org/10.1038/s41598-025-14756-9
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16 czerwca, 2025

Konkurs FameLab 2025

Nabór zgłoszeń do FameLab Poland 2025 trwa od 15 czerwca do 15 września 2025 r.
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15 maja, 2024

Publikacja: Hydrops fetalis caused by a complex congenital heart defect with concurrent hypoplasia of pulmonary blood vessels and lungs visualized by micro-CT in a French Bulldog

IF=2,6 MNiSW=140; BMC Veterinary Research volume 20, Article number: 189 (2024); https://doi.org/10.1186/s12917-024-04060-5
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11 kwietnia, 2024
Canine osteosarcoma (OSA) is an aggressive bone neoplasia with high metastatic potential. Metastasis is the main cause of death associated with OSA, and there is no current treatment available for metastatic disease. Proteomic analyses, including matrix-assisted laser desorption/ionisation-time of flight mass spectrometry (MALDI TOF/TOF MS), are widely used to select molecular targets and identify proteins that may play a key role in primary tumours and at various steps of the metastatic cascade. The main aim of this study was to identify proteins differently expressed in canine OSA cell lines with different malignancy phenotypes (OSCA-8 and OSCA-32) compared to canine osteoblasts (CnOb). The intermediate aim of the study was to compare canine OSA cell migration capacity and assess its correlation with the malignancy phenotypes of each cell line. Using MALDI-TOF/TOF MS analyses, we identified eight proteins that were significantly differentially expressed (p 0.05) in canine OSA cell lines compared to CnOb: cilia- and flagella-associated protein 298 (CFAP298), general transcription factor II-I (GTF2I), mirror-image polydactyly gene 1 protein (MIPOL1), alpha-2 macroglobulin (A2M), phosphoglycerate mutase 1 (PGAM1), ubiquitin (UB2L6), ectodysplasin-A receptor-associated adapter protein (EDARADD), and leucine-rich-repeat-containing protein 72 (LRRC72). Using the Simple Western technique, we confirmed high A2M expression in CnOb compared to OSCA-8 and OSCA-32 cell lines (with intermediate and low A2M expression, respectively). Then, we confirmed the role of A2M in cancer cell migration by demonstrating significantly inhibited OSA cell migration by treatment with A2M (both at 10 and 30 mM concentrations after 12 and 24 h) in a wound-healing assay. This study may be the first report indicating A2M’s role in OSA cell metastasis; however, further in vitro and in vivo studies are needed to confirm its possible role as an anti-metastatic agent in this malignancy.

Publikacja: Proteomic Analyses Reveal the Role of Alpha-2-Macroglobulin in Canine Osteosarcoma Cell Migration

IF=5,6; MNiSW=140; Int. J. Mol. Sci. 2024, 25(7), 3989; https://doi.org/10.3390/ijms25073989
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28 listopada, 2023

Platynowy medal dla zespołu dr hab. Michała Godlewskiego, prof. SGGW

"Novel iron supplementation strategy based on biodegradable iron-doped ZnO nanoparticles".
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23 października, 2023

JEDNO ZDROWIE

26.10.2023 r. - Sesja naukowa: Postęp badań naukowych nad bezpieczeństwem żywności pochodzenia zwierzęcego w świetle koncepcji „Jedno Zdrowie”
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17 października, 2023

Publikacja: Modulation of chicken gut contractility by Melissa officinalis—ex vivo study

IF=4,4; MEiN= 140; https://doi.org/10.1016/j.psj.2023.103045
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14 września, 2023

Konferencja Naukowa „100 lat restytucji żubra”

W dniach 6-8 września 2023 r. w Borku k. Bochni w Małopolsce odbyła się Konferencja Naukowa „100 lat restytucji żubra” zorganizowana przez Stowarzyszenie Miłośników Żubrów...
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10 lipca, 2023

Wykład Profesor Sujin Lee pt.: Strategies for Combating Viral Infections

Wykład odbędzie się 25 lipca 2023 o godz. 11.00, w sali 2004 w budynku 23, (transmisja w MS Teams).
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14 czerwca, 2023

Wykład prof. Marii Fedoriak na temat ukraińskiego pszczelarstwa

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